Evidence map›Paper›PMID 41079829›Full record

ArticleClinical case reports2025

Efficacy of Dupilumab in a Woman With Severe Asthma Complicated by Eosinophilic Sinusitis and a Desire to Have a Baby: A Case Report.

Akari Neoi, Masakiyo Yatomi, Yurino Nagata, Daisuke Higeta, Daisuke Shimizu, Karin Kuno, Yuri Sawada, Mari Sato, Haruka Aoki-Saito, Koichi Yamaguchi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Akari NeoiDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Masakiyo YatomiDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.ORCID https://orcid.org/0000-0001-6840-515X
Yurino NagataDepartment of Otolaryngology-Head and Neck Surgery Gunma University Graduate School of Medicine Maebashi Japan.
Daisuke HigetaDepartment of Obstetrics and Gynecology Gunma University Hospital Maebashi Japan.
Daisuke ShimizuDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Karin KunoDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Yuri SawadaDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Mari SatoDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Haruka Aoki-SaitoDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Koichi YamaguchiDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Hiroaki TsurumakiDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Yosuke MiuraDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Kenichiro HaraDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Noriaki SunagaDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.ORCID https://orcid.org/0000-0002-5966-4579
Yasuhiko KogaDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.
Kazuaki ChikamatsuDepartment of Otolaryngology-Head and Neck Surgery Gunma University Graduate School of Medicine Maebashi Japan.
Takeshi HisadaMedical Corporation Sanshikai Toho Hospital Midorishi Japan.
Toshitaka MaenoDivision of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dupilumab is an effective biologic therapy for severe asthma; however, its safety and efficacy in women undergoing infertility treatment remain uncertain. A woman in her late 30s with severe asthma and eosinophilic chronic rhinosinusitis underwent assisted reproductive technology while receiving dupilumab. The medication was discontinued upon confirmation of pregnancy. Asthma control improved significantly with dupilumab. The patient conceived successfully and delivered a healthy infant. Dupilumab may be a viable treatment option for women with severe asthma undergoing fertility treatment, though additional safety data are needed to support its use during conception and pregnancy.

Indexed as

dupilumabeosinophilic sinusitisinfertility treatmentpregnant womensevere asthma

Identifiers

PMID41079829
PMCPMC12507507

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.