ArticleClinical case reports2025
A Case of Ethmocephaly in a Clomiphene Citrate Induced Pregnancy: A Case Report and Literature Review.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- A Case of Ethmocephaly in a Clomiphene Citrate Induced Pregnancy: A Case Report and Literature Review.Clinical case reports · 2025Article
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8 authors.
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Abstract
Ethmocephaly is the most severe form of holoprosencephaly, which results from incomplete cleavage of the forebrain during embryogenesis. It is incompatible with life. Here we reported a case of ethmocephaly in a clomiphene citrate induced pregnancy in a 32-year-old, gravida 6 woman, at a gestational age of 23 weeks. Upon ultrasound scanning, there were brain abnormalities, like a single dilated ventricle, absent falx cerebri, and facial profile abnormalities like proboscis. After delivery, on physical examination of the newborn, we found ocular hypotelorism, a 5 cm midline proboscis located above the eyes, and absent nasal structures. The patient had used clomiphene for two cycles prior to conception, with no other notable medical history. In conclusion, ethmocephaly is a severe and typically fatal condition requiring early prenatal detection for better planning. While there is no clear link between clomiphene use and holoprosencephaly, further research is needed to explore any potential risks and guide clinical practice.
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