Validation of breast cancer as a risk factor for anxiety and depression: Insights from Mendelian randomization analysis.

Guannan He, Man Xi, Tianhao Zhang, Shuang Wang, Gang Liu

Abstract read

In one paragraph

Article in Journal of pharmaceutical analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Anti-Inflammatory and Antioxidant Effects of ω-3 Polyunsaturated Fatty Acids on Astrocytes and Their Implications for the Blood-Brain Barrier's Integrity and Function.International journal of molecular sciences · 2026
Review
Depression and breast cancer: research progress and prospects from an interdisciplinary perspective.Frontiers in immunology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guannan HeDepartment of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Man XiDepartment of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Tianhao ZhangDepartment of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Shuang WangDepartment of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Gang LiuDepartment of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study employed Mendelian randomization (MR) analysis to confirm the association between breast cancer and the risk of anxiety and depression, and to explore the molecular mechanisms by which lipid nanoparticles of ketamine (LNP@Ket) modulate these behaviors in a mouse model of breast cancer. Through single-cell transcriptomic analysis, the study aimed to clarify nuclear factor erythroid 2-related factor 2 (Nrf2)'s role in the development of anxiety and depression in these mice. Analysis of patient data from genome-wide association study (GWAS) databases supported the link between breast cancer, anxiety, and depression.

Indexed as

Anxiety and depression behaviorsAstrocytesBreast cancerHigh-throughput transcriptome sequencingKetamine-loaded lipid nanoparticlesMendelian randomization analysisNrf2Single-cell transcriptome sequencing

Identifiers

PMID41079789

DOI10.1016/j.jpha.2025.101378

PMCPMC12513017

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.