ArticleComputational and structural biotechnology journal2025
Application of single-cell deep learning in elucidating the mapping relationship between visceral and body surface inflammatory patterns.
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- In Situ Construction of Fascial Analogues Induced by Low-Growth-Factor Matrigel.Animals : an open access journal from MDPI · 2026Article
- Telocytes Twenty Years on: A Critical Reappraisal of Identity, Function, and Pathological Relevance.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subcutaneous fascia (scFascia) is a widely distributed connective tissue, yet its contribution to systemic responses during visceral inflammation remains insufficiently defined. In the rat model of Salmonella-induced dysentery, scRNA-seq of scFascia combined with deep neural network (DNN)-based nonlinear feature discovery revealed transcriptional alterations indicative of Warburg-like reprogramming in macrophages (MPs), accompanied by reduced activity of the citrate cycle. Cd34 + /Pdgfra+ telocytes (CPTCs) regulated MP differentiation and proliferation through Wnt/Fgf signaling, suggesting a pathological communication pattern between scFascia and visceral organs, termed the fascia-visceral inflammatory crosstalk pattern (FVICP). PySCENIC analysis showed increased activity of transcription factors Fosl1, Nfkb2, and Atf4, modulated by CPTC signaling to MPs, leading to downregulation of aerobic respiration and upregulation of the cell cycle, DNA replication, and transcription. Co-culture assays demonstrated that CPTCs suppressed the pro-inflammatory activity of MPs by transcriptionally downregulating TLR4 and CPT1A while upregulating ATF4, and enhanced anti-inflammatory potential via post-transcriptional MTOR upregulation. These findings highlight the role of scFascia in immunomodulation and metabolic reprogramming during visceral inflammation, emphasizing its contribution to systemic homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.