ArticleBrain communications2025
Myelin-water imaging and multi-shell diffusion-weighted imaging in adults with adrenoleukodystrophy.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy.Annals of clinical and translational neurology · 2026Review
- Use of Brain MRI in Cerebral Adrenoleukodystrophy: International Recommendations for Screening, Monitoring, and Research.Neurology · 2026Article
- Lipid signature in X-ALD: a comparison between phenotypes.Frontiers in molecular biosciences · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of X-linked adrenoleukodystrophy (ALD) is not well-understood. New quantitative MRI (qMRI) sequences, such as myelin-water imaging (MWI) and multi-shell diffusion-weighted imaging (DWI), are non-invasive techniques that can investigate microstructural abnormalities in the brain. Using these techniques, this study investigated abnormal white matter of cerebral ALD (cALD) lesions and normal-appearing white matter (NAWM) in ALD and in controls. Adult participants were scanned on 3T MRI scanners. Fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD) were measured with diffusion tensor imaging (DTI). The neurite density index (NDI) was established using neurite orientation dispersion and density imaging (NODDI). Myelin water fractions (MWF) were evaluated with multi-compartment relaxometry diffusion-informed MWI (MCR-DIMWI) and multi-echo T2-relaxation imaging with compressed sensing (METRICS). Measures were evaluated in 10 regions of interest (ROIs) in participants with and without cALD, and in controls. A total of 81 ALD participants (69% males, of whom 17 had cALD), and 21 controls were included. FA, NDI, MWF
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