ArticleFrontiers in pharmacology2025
Stable interindividual differences in modafinil's effect on vigilance during sleep deprivation.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- If Not All Paths Lead to Mental Fatigue, Perhaps Mental Fatigue Is Not the Destination.Sports medicine (Auckland, N.Z.) · 2026Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Rationale: In specific operational contexts (i.e., military aviation), the off-label use of modafinil is officially regulated. However, safety concerns are still raised. Objectives: To study the stability and robustness of interindividual differences in modafinil sensitivity, both in terms of risks and benefits in military student pilots. Methods: Eleven healthy military student pilots (21 ± 2 yr; 1 woman) were tested in a within-subject randomized counterbalanced crossover design to compare modafinil (2 × 200 mg; EXP) vs. placebo (CON) effects during extended wakefulness (24 h). Throughout both trials, participant's vital signs, mood, vigilance [i.e., Psychomotor Vigilance Task (PVT)] and self-monitoring ability were measured. Additionally, four participants were genotyped [i.e., COMT (rs4680) and PER3 (rs228697)]. We used Pearson correlation coefficients to evaluate the relationship between PVT performance and the performance self-monitoring scores. To evaluate the stability of interindividual differences in the effectiveness of modafinil to improve PVT performance and sleepiness, an intraclass correlation coefficient (ICC) was calculated for the delta score (CON-EXP) of both outcome measures. Results: Modafinil significantly improved PVT performance (p ≤ 0.034) and sleepiness (p ≤ 0.029) at 2a.m. and 4a.m. during the sleep deprivation night. The stability of the non-adjusted reaction time-delta score was very high (ICC = 0.90). Non-adjusted reaction time only correlated with the performance self-monitoring scores in CON (r ≥ -0.35; p < 0.001). Conclusion: Stable interindividual differences in the effectiveness of modafinil to counteract the sleep deprivation-associated decrease in vigilance exist. Further research should focus on quantifying the extent to which modafinil-induced overconfidence and subjective rebound sleepiness actually constitute potential problems in operational environments (e.g., perhaps using war game simulations).
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