ArticleArthroplasty today2025
Malnutrition is Common in Patients Utilizing Glucagon-Like Peptide-1 Agonists Prior to Total Joint Arthroplasty.
Article in Arthroplasty today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Nutritional optimization for older adults undergoing hip fracture surgery: a randomized controlled pilot trial.OTA international : the open access journal of orthopaedic trauma · 2026Article
- Glucagon-Like Peptide-1 Receptor Agonist-Based Agents and Body Composition: Filling More Gaps.Obesity (Silver Spring, Md.) · 2026Review
- Post Weight Loss Body Contouring Surgery: Complication Rates Following Bariatric Surgery, Injectable Glucagon-like Peptide-1 Receptor Agonist Pharmacotherapy, Combination Therapy, and Lifestyle Modification.Aesthetic surgery journal · 2026Article
- Avoiding Malnutrition in the Era of Glucagon-Like Peptide-1 Medications: Emerging Evidence and Opportunities for Integrated Nutrition Care.The Journal of nutrition · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The rising prevalence of obesity and the increased use of glucagon-like-peptide-1 (GLP-1) receptor agonists for weight loss and diabetes has led to more patients qualifying for elective total joint arthroplasty (TJA). While these medications promote weight reduction, they may predispose patients to nutritional deficiencies. This study aims to evaluate the preoperative nutritional status of GLP-1 users undergoing TJA compared to nonusers. Methods: A retrospective chart review was conducted at a high-volume center on patients who underwent elective primary TJA between January 1 and May 1, 2025. Patients were included if they had complete preoperative nutritional labs. Nutritional markers included hemoglobin, albumin, total protein, prealbumin, calcium, alkaline phosphatase, and 25-hydroxy vitamin D. Malnutrition was defined as ≥1 laboratory deficiency; severe malnutrition as ≥2 deficiencies. GLP-1 use, indication, and duration were recorded. Statistical analyses included t-tests, chi-square tests, and odds ratio calculations. Results: A total of 165 patients met inclusion criteria, with 29 (17.6%) actively using GLP-1 receptor agonists. The cohorts were matched for comorbidities. GLP-1 users had higher rates of malnutrition (38% vs 8.8%, Conclusions: GLP-1 agonist use is associated with significantly higher rates of preoperative nutritional deficiencies in patients undergoing elective TJA. Given the high risk of malnutrition in this growing patient population, targeted nutritional screening and optimization should be considered standard practice in the preoperative evaluation of GLP-1 users.
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