Evidence map›Paper›PMID 41079618›Full record

ArticleiScience2025

NKp30 and NKG2D contribute to natural killer cell-mediated recognition of HIV-infected cells.

Ruoxi Pi, Nancy Q Zhao, Allison J Bien, Thanmayi Ranganath, Christof Seiler, Susan Holmes, Alexander Marson, David N Nguyen, Catherine A Blish

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. CD8medRxiv : the preprint server for health sciences · 2025
    Article
  6. Natural Resistance to HIV Infection: Role of Immune Activation.Immunity, inflammation and disease · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ruoxi PiDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Nancy Q ZhaoDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Allison J BienInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Thanmayi RanganathDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.
Christof SeilerDepartment of Advanced Computing Sciences, Maastricht University, Maastricht, the Netherlands.
Susan HolmesDepartment of Statistics, Stanford University, Stanford, CA, USA.
Alexander MarsonInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
David N NguyenInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Catherine A BlishDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.

Funding

X-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMERMAN, MICHAEL · 2019 to 2021
$14.4M
Inherited T cell defects: Diagnosis, Mechanisms and TreatmentsP01AI138962 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2020 to 2024
$11.3M
Targeting natural killer cells to HIV in intravenous drug usersDP1DA046089 · NIDA · STANFORD UNIVERSITY · PI BLISH, CATHERINE A · 2018 to 2022
$3.9M
Natural killer cell engineering to target the HIV reservoirR01AI161803 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLISH, CATHERINE A, ZACK, JEROME A. · 2021 to 2025
$3.8M
CRISPR Editing of Primary Human Cells to Model and Correct Primary Immunodeficiency MutationsK08AI153767 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NGUYEN, DAVID-HUY NHU · 2020 to 2024
$994k
NIAID NIH HHS K08 AI153767NIAID NIH HHS P01 AI138962NIAID NIH HHS P50 AI150476NIAID NIH HHS R01 AI161803NIDA NIH HHS DP1 DA046089
6 · The paper itself

Abstract

Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous newly HIV-infected CD4 T cells

Indexed as

Biological sciencesImmunityImmunologyNatural sciences

Identifiers

PMID41079618
PMCPMC12514549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.