ArticleiScience2025
Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions.The European journal of neuroscience · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated ion channels and glutamate receptors. However, OPCs display regional and temporal diversity in the membrane surface expression of these channels and receptors, altering their capacity to sense and respond to neuronal activity. Here, we use whole-cell patch-clamp in acute brain slices and bath-apply 3 μM kainate or 10 μM AMPA to investigate the heterogeneity in kainate and AMPA receptor membrane surface expression. We find that, while kainate receptor current density remains stable with age, OPCs do not respond to neuronal kainate receptor-specific drugs. In contrast, AMPA receptor current density differs with age and between regions, likely due to altered Ca
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