ArticleiScience2025
Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A Synchronization-Driven Learning Rule for Pattern Separation in Self-Organizing Probabilistic Spiking Neural Networks.Research square · 2026Article
- Icariin Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulation of LCN2-MEK/ERK Signaling-Associated Neuroinflammation.CNS neuroscience & therapeutics · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Spatial working memory enables behavioral flexibility and depends upon the hippocampus. The hippocampal dentate gyrus (DG) is hypothesized to act as a pattern separator to disambiguate similar memories. We used activity-dependent labeling strategies in DG to tag multiple memory-associated neuronal ensembles recruited during the course of learning a spatial working memory task. We termed the tagged ensembles "nonspecific" because they arose from experiences across days, maze arenas, and the home cage. Optogenetic stimulation of nonspecific ensembles during the encoding phase within random trials of the task acutely impaired performance during light-on trials only. The degree of reactivation in the dentate hilus, but not the blade, inversely correlated with task accuracy. While our results do not rule out the possibility that the stimulation of random, sparse DG ensembles could lead to similar impairment, they are consistent with the proposed role of DG in pattern separation, completion, and spatial working memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.