ArticleiScience2025
Sparse memory ensembles set brain-wide network states to sustain learned associations.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies.Frontiers in behavioral neuroscience · 2026Article
- Mapping memory at scale: systems-level insights with translational and transdiagnostic relevance to fear-related disorders.Frontiers in behavioral neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to recall spatial memories and adapt behavior to changing conditions underlies efficient navigation. These processes are thought to rely on sparse populations of neurons, embedded within distributed brain networks. Here, we sought to address how these neurons impact large-scale network connectivity to sustain behavior. We tagged neurons that were active during an appetitive spatial memory task in TetTag-hM3Dq mice and chemogenetically reactivated these ensembles during fMRI. The reactivation of these ensembles triggered widespread network reorganization, optimizing modular specialization while maintaining integration via key hubs and gateways. We identified distinct clusters dominated by the ventral and dorsal hippocampus that exhibit unique connectivity with cortical and subcortical areas. While control mice showed effective extinction learning (EL), reactivating the tagged memory ensembles prevented EL. These findings reveal brain-wide hubs that support spatial memory and indicate that decay of this network connectivity is likely an essential facet of effective EL of spatial experience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.