Evidence map›Paper›PMID 41079608›Full record

ArticleiScience2025

Alphavirus replicons encoding IFN-γ enhance cancer virotherapy by overcoming macrophage-mediated suppression.

Laura Horvathova, Priscilla Kinderman, Thijs Janzen, Baukje Nynke Hoogeboom, Franz J Weissing, Nadine van Montfoort, Toos Daemen, Darshak K Bhatt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura HorvathovaDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Priscilla KindermanDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Thijs JanzenGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Baukje Nynke HoogeboomDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Franz J WeissingGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Nadine van MontfoortDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Toos DaemenDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Darshak K BhattDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interference by tumor-associated macrophages may significantly reduce the efficacy of therapeutic viruses designed to infect cancer cells and activate anti-tumor T cells. Using a computational model, we hypothesized that viruses encoding a T cell-stimulating signal, like interferon-gamma (IFN-γ), could overcome this barrier. We engineered an alphavirus-based replicon expressing IFN-γ and evaluated its effect in various human-derived tumor-immune coculture systems and an

Indexed as

biological sciencescancer systems biologyImmunologyNatural sciencessystems biology

Identifiers

PMID41079608
PMCPMC12508886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.