ArticleFrontiers in cardiovascular medicine2025
Positive association between Cheyne-Stokes respiration events and diastolic dysfunction in pre-heart failure: a cross-sectional study with longitudinal implications.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Prevalence and management of residual respiratory events in OSA patients treated with CPAP: a prospective observational clinical experience.Sleep & breathing = Schlaf & Atmung · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cheyne-Stokes respiration (CSR), a distinct type of sleep-related breathing disorder, is closely associated with heart failure (HF). In clinical practice, it has been observed that some patients with CSR do not present with HF or related symptoms. However, limited studies have investigated this phenomenon. This study aimed to explore whether CSR events may indicate specific cardiac structural/functional alterations or serve as an early warning sign for HF progression. Materials and methods: We enrolled middle-aged and elderly patients (≥45 years) hospitalized at Guangdong Provincial Hospital of Traditional Chinese Medicine without a diagnosis or symptoms of HF. Data on medical history, echocardiography, BNP/NT-proBNP levels, and polysomnography were collected. Participants were categorized into three groups based on PSG results: (1) Sleep-Related breathing disorders with CSR, (2) Sleep-Related breathing disorders without CSR, and (3) no Sleep-Related breathing disorders. Comparative analyses of clinical parameters were performed across groups. Results: A total of 171 patients were included. Patients with CSR events exhibited significantly higher BNP/Nt-proBNP levels and more pronounced cardiac structural remodeling, including left atrial enlargement and elevated E/e' ratios. Further analysis identified CSR events as independent risk factors for elevated BNP/Nt-proBNP levels [OR = 2.02, 95%CI (1.02-3.98), Conclusion: In patients without overt HF, the presence of CSR events is positively correlated with left ventricular diastolic dysfunction. CSR events may serve as a biomarker for persistent cardiac diastolic impairment or an early indicator of pathological progression toward heart failure with preserved ejection fraction (HFpEF). These findings warrant further longitudinal investigations to validate its predictive value in clinical settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.