Predictive value of the quantitative flow ratio after pretreatment and drug-coated balloon therapy for functional stenosis of target vessels at the mid-term follow-up.

Xinjun Lin, Yuwei Chen, Wanjun Huang, Zhendong Cheng, Bin Yu, Wei Ji, Yaoguo Wang, Chaoxiang Xu

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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Xinjun Lin *The Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Yuwei Chen *The Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Wanjun Huang *The Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Zhendong ChengThe Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Bin YuThe Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Wei JiThe Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Yaoguo WangThe Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Chaoxiang XuThe Second Clinical College of Fujian Medical University, Quanzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Drug-coated balloon (DCB) treatment requires adequate preconditioning of target lesions. The quantitative flow ratio (QFR) is an emerging method for assessing functional stenosis of coronary arteries. This study investigated the predictive value of the QFR after pretreatment and DCB treatment for functional stenosis of the target vessel at the mid-term follow-up. Methods: The study included patients with coronary heart disease who received DCB treatment. The patients were divided into two groups based on their functional stenosis status at follow-up. Independent predictors associated with functional stenosis and the effects of the pretreatment QFR on outcomes were investigated. A receiver operating characteristic curve analysis was used to determine the pretreatment QFR cutoff value associated with follow-up QFR >0.80. The mediating effects of the QFR after pretreatment and DCB treatment on outcomes were also examined. Results: The study included 97 target vessels from 97 patients; the median follow-up time was 297.0 days. The high (QFR >0.80) and low (QFR ≤0.80) QFR groups included 78 and 19 vessels, respectively. Multifactor logistics regression analysis identified the pretreatment QFR as an independent predictor of outcome. The pretreatment QFR cutoff value for predicting functional stenosis was 0.705. The DCB-treatment QFR did not elicit mediating effects on the follow-up QFR. Conclusions: The QFR after pretreatment directly and significantly affected the follow-up QFR. Pretreatment QFR <0.705 may be a valuable predictor of functional stenosis after DCB treatment.

Indexed as

drug-coated balloonfunctional stenosispretreatmentquantitative flow ratiotarget vessel

Identifiers

PMID41079583

DOI10.3389/fcvm.2025.1610386

PMCPMC12509214

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