Evidence map›Paper›PMID 41079499›Full record

ReviewCureus2025

Analgesic Effectiveness of Magnesium Sulfate as an Adjuvant to Local Anesthesia in Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Abdulwahab T Alenezi, Abdalla Alenezi, Salem Albadi, Abullah A Bakheet, Fawaz Alshammari, Abdulmuhsen F Alajmi, Mohammed Alkandari, Alya Almulla, Yousef Alqattan, Shahad Altaweel and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abdulwahab T AleneziDepartment of Dentistry, Saad Al-Abdullah Block 2 Polyclinic, Al-Jahra, KWT.
Abdalla AleneziDepartment of Dentistry, Qasr Polyclinic, Al-Jahra, KWT.
Salem AlbadiDepartment of Dentistry, Kuwait National Guard Hospital, Kuwait City, KWT.
Abullah A BakheetDepartment of Dentistry, Kuwait Institute for Medical Specializations, Kuwait City, KWT.
Fawaz AlshammariDepartment of Dentistry, Kuwait Institute for Medical Specializations, Kuwait City, KWT.
Abdulmuhsen F AlajmiDepartment of Dentistry, Kuwait Institute for Medical Specializations, Kuwait City, KWT.
Mohammed AlkandariDepartment of Dentistry, Rumaithiya Polyclinic, Kuwait City, KWT.
Alya AlmullaDepartment of Dentistry, Omariya Polyclinic, Farwaniya, KWT.
Yousef AlqattanDepartment of Dentistry, Sabah Al-Salem Polyclinic, Kuwait City, KWT.
Shahad AltaweelDepartment of Dentistry, Rumaithiya Polyclinic, Kuwait City, KWT.
Turki J AlshammariDepartment of Dentistry, Jahra Polyclinic, Al-Jahra, KWT.
Shouq AlshattiDepartment of Dentistry, Mubarak Al-Kabeer Eastern Medical Center, Mubarak Al-Kabeer, KWT.
Abdulaziz AlmuthaybiriDepartment of Dentistry, Al-Jahra Specialized Dental Center, Al-Jahra, KWT.
Duaij AlsenafiDepartment of Dentistry, Kuwait Institute for Medical Specializations, Kuwait City, KWT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inferior alveolar nerve block (IANB) is the most commonly used method for inducing pulpal anesthesia in patients with symptomatic irreversible pulpitis (SIP). Magnesium sulfate has been reported to increase the anesthetic effectiveness for endodontic procedures. Whether the adjuvant use of magnesium sulfate with IANB is effective in SIP patients remains uncertain. We performed an electronic search on PubMed, Scopus, Web of Science (WOS), and Cochrane CENTRAL from inception to September 2025 for randomized controlled trials (RCTs) assessing the adjuvant use of magnesium sulfate with IANB and local anesthesia compared to IANB with local anesthesia alone in patients with SIP. The primary outcome of interest was the pain scores following one and two hours post-procedure, while the secondary outcome was the anesthetic success rates. Standardized mean difference (SMD) and risk ratio (RR) with their 95% confidence intervals (CIs) were calculated using a random effects model. All analyses were performed using STATA 19MP. Seven RCTs comprising 398 patients were included in the final analysis. The adjuvant use of magnesium sulfate was associated with significant reductions in post-procedure pain scores at one hour (SMD = -1.97, 95% CI: -3.18 to -0.77,

Indexed as

inferior alveolar nerve block (ianb)magnesium sulfatemeta-analysissymptomatic irreversible pulpitissystematic review

Identifiers

PMID41079499
PMCPMC12509777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.