ArticleCureus2025
Autoimmune Encephalitis With Positive Anti-Leucine-Rich Glioma-Inactivated 1 (Anti-LGI1) Antibody Mimicking Psychogenic Non-epileptic Seizures.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Autoimmune encephalitis (AIE) represents a significant cause of neurological and psychiatric disorders, often initially misdiagnosed due to a diverse clinical presentation. This case describes a middle-aged woman initially diagnosed with psychogenic non-epileptic seizures (PNES) following emotional stress and depressive symptoms after a family bereavement. Progressive involuntary jerky movements, cognitive dysfunction, and a generalized tonic-clonic seizure raised suspicion for AIE. Diagnostic imaging showed medial temporal lobe hyperintensities, and serological testing confirmed high titers of anti-leucine-rich glioma-inactivated 1 (LGI1) antibodies. The patient showed significant improvement after receiving pulse steroid therapy and intravenous immunoglobulin (IVIG). This case highlights the importance of recognizing psychiatric and neurological overlap in anti-LGI1 encephalitis, emphasizing the need for prompt diagnostic evaluation and early immunomodulatory treatment to optimize patient outcomes.
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