ArticleJournal of biomedical optics2025
Optical coherence elastography detects increased corneal stiffness in nonhuman primates with experimental glaucoma.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- Editorial: Advances in Optical Elastography.Journal of biomedical optics · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Significance: Glaucoma is a leading cause of irreversible blindness, characterized by progressive optic nerve damage. Early detection of glaucoma is key to effective intervention, but an incomplete clinical understanding of the development of glaucoma complicates the selection of diagnostic criteria. Prolonged ocular hypertension due to glaucoma can impact the biomechanical properties of ocular tissues, including the cornea. We examine whether experimental glaucoma causes changes in the biomechanical properties of the cornea. Aim: We determined the biomechanical properties of the cornea in a nonhuman primate model of unilateral experimental glaucoma and compared them with the fellow, untreated control eyes using optical coherence elastography (OCE) to determine if prolonged intraocular pressure (IOP) elevation causes changes in corneal stiffness. Approach: Experimental glaucoma was induced in one eye ( Results: Our results show a significant ( Conclusions: These results show the potential of wave-based OCE methods for assessing stiffness changes in the cornea caused by remodeling due to chronic pressure elevation.
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Registered trials
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