Evidence map›Paper›PMID 41079362›Full record

ArticleFrontiers in neurology2025

Alkaline phosphatase predicts short-term postoperative outcome in adult patients with moyamoya disease.

Wei Sun, Huihui Wang, Qiheng He, Junsheng Li, Chenglong Liu, Zhiyao Zheng, Siqi Mou, Bojian Zhang, Zhikang Zhao, Chuming Tao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extracellular vesicles in spine tumors: biological roles, immune modulation, and therapeutic implications.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wei Sun *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Huihui Wang *Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China.
Qiheng He *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Junsheng LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chenglong LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhiyao ZhengDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Siqi MouDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Bojian ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhikang ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chuming TaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiangjun ShiChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Yan ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peicong GeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dong ZhangDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Jun WuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alkaline phosphatase (ALP) has played a pivotal role in vascular diseases in recent years. However, the association between ALP level and postoperative complications of moyamoya disease (MMD) has not been studied. Patients and methods: Blood samples were collected from recruited patients with MMD. The serum ALP concentrations of the patients were determined using non-frozen specimens via an automated enzymatic assay. Patients were then divided into two groups according to the median, and a comparative analysis was performed. Patients were stratified into two cohorts for statistical evaluation based on the occurrence of postoperative stroke events. We employed a nomogram to identify risk factors for postoperative events. We also created a Cox model to analyze the risk factors for postoperative stroke events, including ALP. Furthermore, we plotted a restricted cubic spline (RCS) of ALP concentration vs. postoperative stroke events. Results: We could find that the ALP concentration of non-postoperative stroke group and postoperative stroke group was 68.70 U/L and 71.15 U/L. This nomogram showed that ALP was a risk factor for postoperative events, and the Hosmer-Lemeshow goodness-of-fit test was employed, suggesting that the model was reliable (χ Conclusions: ALP levels may predict the short-term postoperative outcomes of MMD patients undergoing surgical treatment.

Indexed as

alkaline phosphatasebiomarkermoyamoya diseaseoutcomepostoperative

Identifiers

PMID41079362
PMCPMC12510858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.