ArticleF1000Research2025
Effect of Stem Cells from Human Exfoliated Deciduous Teeth Spent Medium (SHED-SM) on the Healing of Traumatic Buccal Mucosal Ulcers.
Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Green tea (Journal of Taibah University Medical Sciences · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Traumatic ulcers are among the most prevalent injuries with a reported incidence of up to 95%. This study aims to evaluate Stem Cells from Human Exfoliated Deciduous Teeth Spent Medium (SHED-SM) nanoemulgel on the viability cells of NIH-3T3 and buccal mucosal ulcer wounds. Materials and methods: The viability cells test of SHED-SM was analyzed on NIH-3T3 fibroblast cells using MTT. Thirty male Wistar rats, 2-3 months, were used as experimental subjects. Traumatic ulcer models were created by excising the right buccal mucosa with a 3 mm punch biopsy. Subjects were divided into 2 groups @15 rats for the treatment (SHED-SM) and control. The gel was applied on the surface once a day for 4 days. Evaluation was conducted on days 1, 3, 5, 7, and 14. Hematoxylin Eosin (HE) and immunohistochemical were stained to evaluate a number of neutrophils and the expression of COX-2, VEGF, and Col-1. Results: The one-way ANOVA results showed significant differences in the viability test, the number of neutrophils, and the expression of COX-2, Col-1, and VEGF. The number of neutrophils and the expression of COX-2, Col-1, and VEGF were higher in the treatment group compared to the control. Conclusion: SHED-SM demonstrates potential to accelerate the healing of traumatic buccal mucosal ulcers.
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