Evidence map›Paper›PMID 41079254›Full record

ArticleOncoscience2025

Metastatic breast cancer with leptomeningeal carcinomatosis treated with trastuzumab deruxtecan - a case report.

Cristiana Honrado Martins, José Miguel Rocha, Catarina Portela, Ricardo Fernandes, Cláudia Caeiro

Abstract readCase Reports
In one paragraph

Article in Oncoscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cristiana Honrado MartinsMedical Oncology Resident, Medical Oncology Department, Hospital de Braga, ULS de Braga, Braga 4710-243, Portugal.
José Miguel RochaMedical Oncology Resident, Medical Oncology Department, Hospital de Braga, ULS de Braga, Braga 4710-243, Portugal.
Catarina PortelaMedical Oncology Specialist, Medical Oncology Department, Hospital de Braga, ULS de Braga, Braga 4710-243, Portugal.
Ricardo FernandesMedical Oncology Specialist, Medical Oncology Department, Hospital de Braga, ULS de Braga, Braga 4710-243, Portugal.
Cláudia CaeiroMedical Oncology Specialist, Medical Oncology Department, Hospital de Braga, ULS de Braga, Braga 4710-243, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most common malignancy in women. Both histology and immunochemistry are core to treatment choice and the knowledge of these fields is expanding. Metastatic breast cancer (MBC) has significantly lower overall survival (OS) than early stages, and leptomeningeal carcinomatosis (LMC) and brain metastasis (BM) have particularly worse prognosis. We describe a case of LMC BC treated with trastuzumab-deruxtecan (T-DXd). Thirty-seven years old woman, diagnosed with a HER2-positive invasive lobular carcinoma (cT2N0M0). After initial treatment with neoadjuvant chemotherapy plus anti-HER2 double blockade, surgery and postoperative radiotherapy, the patient relapsed with

Indexed as

antibody-drug conjugatebreast cancerHER2 positiveleptomeningeal carcinomatosistrastuzumab-deruxtecan

Identifiers

PMID41079254
PMCPMC12509423

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.