Evidence map›Paper›PMID 41079225›Full record

ReviewOpen medicine (Warsaw, Poland)2025

A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD.

Yuxin Gai, Mengyi Qian, Guojian Lin, Hujie Zhan, Linhui Fan, Lijing Su

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuxin GaiDepartment of Neurology, Ningbo Yinzhou No. 2 Hospital, Ningbo, 315100, Zhejiang, China.
Mengyi QianDepartment of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Guojian LinSchool of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Hujie ZhanCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China.
Linhui FanThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Lijing SuDepartment of Neurology, Ningbo Yinzhou No. 2 Hospital, 998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although deep brain stimulation (DBS) has been proven to enhance motor function in Parkinson's disease (PD) patients, its potential adverse impact on cognitive function remains ambiguous. This study aimed to explore the effects of DBS on cognitive function in patients with advanced PD. Methods: PubMed, EBSCO, Cochrane Library, Web of Science, and Embase were searched for randomized controlled trials (RCTs) and cohort studies on DBS and advanced PD from inception to January 2025. The main cognitive function assessment tools include but are not limited to Mini-MENTAL State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS). Results: A total of 7 RCTs and 11 cohort studies were included. Analyses reveals no significant differences in MMSE (mean difference [MD] = -0.33, Conclusions: DBS poses a potential risk to cognitive function in patients with advanced PD.

Indexed as

cognitive functiondeep brain stimulationlanguage functionmeta-analysisParkinson’s disease

Identifiers

PMID41079225
PMCPMC12514775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.