Evidence map›Paper›PMID 41079224›Full record

ArticleOpen medicine (Warsaw, Poland)2025

Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction.

Yalei Fan, Xiaomin Xie, Guirong Bai, Wenrui Ji, Yanting He, Li Zhang, Haiyan Zhou, Ling Li, Huan Li, Dan Qiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparative urinary metabolomics reveals unique and shared pathways in COVID-19 and liver diseases.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yalei FanThe Second Clinical Medical School of Ningxia Medical University, Yinchuan, 750001, China.
Xiaomin XieDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Liqun West Street 2, Xingqing District, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Guirong BaiDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Wenrui JiDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Yanting HeDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Li ZhangDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Haiyan ZhouDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Ling LiDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Huan LiDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.
Dan QiangDepartment of Endocrinology, The Second Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 virus infection can cause disorders of the endocrine system. The aim of this study was to characterize the alterations of nucleotide metabolomic patterns in patients with post-COVID-19 condition (PCC). The study population included 18 patients with PCC alone (PCC-A), 31 patients with PCC combined with type 2 diabetes mellitus (PCC-DM), 20 healthy volunteers (HV), and 20 patients with type 2 diabetes mellitus (DM). Ultraperformance liquid chromatography-mass spectrometry was conducted on plasma metabolites. A total of 116, 178, and 163 differential metabolites were identified in PCC-DM vs PCC-A, PCC-A vs HV groups, and PCC-DM vs DM groups, respectively. Adenine was significantly down-regulated, and purine, thymine, and uracil were significantly up-regulated in the PCC-A group compared with the HV group, and the same results were observed in the PCC-DM group compared with the DM group. Differential metabolites were mainly involved in nucleotide metabolism, especially pyrimidine metabolism in PCC patients. After the arginine stimulation test, cortisol and adrenocorticotropic hormone secretion were reduced in PCC patients. In conclusion, the nucleotide

Indexed as

metabolitesnucleotide metabolismpost-COVID-19 conditiontype 2 diabetes mellitusUPLC–MS/MS

Identifiers

PMID41079224
PMCPMC12514782

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.