Evidence map›Paper›PMID 41079216›Full record

ArticleEndoscopy international open2025

Large language model for interpreting the Paris classification of colorectal polyps.

Davide Massimi, Luca Carlini, Yuichi Mori, Luca Di Stefano, Giulio Antonelli, Tommy Rizkala, Marco Spadaccini, Roberto de Sire, Ludovico Alfarone, Chiara Lena and 12 more

Abstract read
In one paragraph

Article in Endoscopy international open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. SurgViVQA: temporally grounded video question answering for surgical scene understanding.International journal of computer assisted radiology and surgery · 2026
    Article
  3. Large Language Model-Driven Analysis and Report Generation of Endoscopy Videos-A Pilot Study.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Davide MassimiIRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0000-0002-0926-514X
Luca CarliniDepartment of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy.
Yuichi MoriInstitute of Health and Society, University of Oslo, Oslo, Norway.ORCID 0000-0003-2262-0334
Luca Di StefanoIRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0009-0002-6295-0071
Giulio AntonelliOspedale dei Castelli, Ariccia, Italy.ORCID 0000-0003-1797-3864
Tommy RizkalaIRCCS Humanitas Research Hospital, Rozzano, Italy.
Marco SpadacciniIRCCS Humanitas Research Hospital, Rozzano, Italy.
Roberto de SireIRCCS Humanitas Research Hospital, Rozzano, Italy.
Ludovico AlfaroneIRCCS Humanitas Research Hospital, Rozzano, Italy.
Chiara LenaDepartment of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy.
Alessandro D'ApranoIRCCS Humanitas Research Hospital, Rozzano, Italy.
Sravanthi ParasaDepartment of Gastroenterology, Swedish Medical Group, WA, United States.
Raf BisschopsDepartment of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium.ORCID 0000-0002-9994-8226
Daniel von RentelnGastroenterology, Centre hospitalier de l'université de Montréal, Montreal, Canada.ORCID 0000-0002-6125-0068
Susanne Margaret O'ReillyCentre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland.ORCID 0000-0002-9220-6465
Victor SavevskiAI Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Prateek SharmaGastroenterology, University of Kansas School of Medicine and VA Medical Center, Kansas City, United States.
Douglas K RexDivision of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, United States.
Michael BretthauerDepartment of Gastroenterology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Elena DemomiDepartment of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy.
Cesare HassanEndoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0000-0001-7167-1459
Alessandro RepiciEndoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and study aims: Reporting of colorectal polyp morphology using the Paris classification is often inaccurate. Multimodal large language models (M-LLMs) may support morphological assessment. This study aimed to evaluate the accuracy of an M-LLM (GPT-4o) in classifying colorectal polyp morphology compared with expert and non-expert endoscopists. Patients and methods: We used the SUN dataset of colonoscopy videos from 100 unique colorectal polyps, each labeled with the validated Paris classification. An M-LLM (GPT-4o) classified five representative frames per lesion. Three expert and three non-expert endoscopists, blinded to one another, performed the same task. The primary outcome was accuracy in differentiating non-polypoid (IIa/IIc) from polypoid (Is/Ip/Isp) lesions. The secondary outcome was accuracy in differentiating sessile (Is) from pedunculated (Ip/Isp) lesions. Given the exploratory design, no multiplicity correction was applied; point estimates are presented with 95% confidence intervals (CIs), and Results: M-LLM accuracy for differentiating non-polypoid from polypoid lesions was 73% (95% CI 63%-81%), comparable to experts (75%, 65%-83%; Conclusions: M-LLMs performed comparably to endoscopists in distinguishing non-polypoid from polypoid lesions but failed to reliably identify pedunculated morphology.

Indexed as

Colorectal cancerCRC screeningDiagnosis and imaging (inc chromoendoscopy, NBI, iSCAN, FICE, CLE...)Endoscopy Lower GI TractPolyps / adenomas / ...Tissue diagnosis

Identifiers

PMID41079216
PMCPMC12511921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.