ArticleJournal of biomedical optics2025
Segmental airway adenocarcinoma-simulating phantom for endoscopic near-infrared optical coherence tomography.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Significance: There is an unmet need for readily accessible imaging targets to verify whether devices can discriminate lesions from healthy tissue and identify sub-surface vasculature in the small airways. Aim: Our aim is to develop a phantom that mimics human segmental airway adenocarcinoma Approach: We develop phantoms using a mixture of agar, intralipid, and coconut oil cured in a 3D printed mold with embedded tubing to mimic vasculature. The parenchyma optical attenuation coefficient (OAC) is calibrated using optical transmission measurements from an agar and intralipid dilution series. Depth-resolved OAC histogram distributions, analysis of variance, and image quality are used to assess repeatability and biofidelity of these phantoms. Results: Transmission measurements show large increases in OAC when intralipid is cured with agar compared with water-intralipid dilutions. Representative phantom OACs show repeatability within 2.7% and match normal Conclusions: The segmental airway phantoms demonstrate
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