ArticleImmunoTargets and therapy2025
Efficacy of Tacrolimus Plus Prednisone as Long-Term Immunosuppressive Therapy for Chronic Inflammatory Demyelinating Polyneuropathy: A Retrospective Cohort Study.
Article in ImmunoTargets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transitioning from efgartigimod to tacrolimus in chronic inflammatory demyelinating polyneuropathy: a prospective case series.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to evaluate the efficacy and safety of tacrolimus as an add-on therapy in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Patients and Methods: This retrospective cohort analysis was conducted using data from CIDP patients in the database of Xuanwu Hospital, Capital Medical University between April 2019 and June 2023. This study compared the efficacy of tacrolimus plus prednisone (T&P) versus prednisone monotherapy (PM) as maintenance immunosuppressive therapy. The primary endpoint was the response rate, defined as ≥1-point improvement in INCAT score, assessed at 3, 6, and 12 months. Secondary endpoints included: (1) I-RODS score changes from baseline to 3, 6, and 12 months; (2) the monthly median daily prednisone dose; (3) relapse rate (INCAT score worsening ≥1 point) in the 12-month follow-up; and (4) adverse event profiles over the 12-month follow-up period. Results: Among 74 screened CIDP patients, 34 (45.9%) were included, with 16 receiving T&P and 18 receiving PM. All patients completed follow-up (median: 1.4 years; range: 1.0-6.5 years). The T&P group demonstrated significantly higher response rates at 3 and 6 months compared to PM, though this difference attenuated by 12 months. I-RODS improvements were significantly greater in the T&P group at all time points. The relapse rate was lower in the T&P group (12.5% vs 33.3%). The T&P group maintained significantly lower prednisone doses from month 2 onward, with higher prednisone discontinuation rates at 12 months (43.8% vs 11.1%; Conclusion: Tacrolimus plus prednisone therapy demonstrated superior clinical outcomes compared to prednisone monotherapy in CIDP maintenance treatment, including accelerated symptomatic improvement, reduced relapse risk, and facilitated corticosteroid tapering. The combination regimen maintained an acceptable safety profile without serious adverse events, supporting its corticosteroid-sparing role in CIDP management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.