ArticleJAC-antimicrobial resistance2025
Spatio-temporal distribution of extended spectrum β-lactamase producing
Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objectives: ESBLs are an important cause of third generation cephalosporin resistance in Enterobacterales. However, there is a paucity of data on ESBLs in blood stream infections (BSI) in Laos. The aim of this study was to investigate the presence of ESBL-producing Methods and materials: This retrospective observational study included blood cultures from patients presenting with fever to Mahosot Hospital between 2000 and 2018. Full identification and antibiotic susceptibility testing was carried out on positive bottles. ESBL production was determined using the double-disc method. Patient clinical and residence data were included in univariable and multivariable analyses to identify risk factors for having an ESBL. Results: From 52 249 blood culture sets collected over the 18-year period, 222 (0.42%) were positive for an ESBLEC or ESBLKP. The proportion of Conclusion: With a rising trend of ESBLEC in Laos, controlling unregulated antibiotic usage in the community will be pivotal to stopping further increases.
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