SynthesisFrontiers in oncology2025
Scientometric analysis of glioblastoma and blood-brain barrier research (1995-2024): evolving trends and therapeutic challenges.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative carbohydrate loading: evolution, trends, and future directions.Frontiers in nutrition · 2026Pooled it
- A bibliometric analysis of research trends in mediastinitis: a rare, high mortality, and complex infectious disease.Journal of thoracic disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Glioblastoma (GBM) is one of the most aggressive neurogenic tumors. Despite advances in treatment, the presence of the blood-brain barrier (BBB) continues to pose significant challenges to effective therapeutic delivery. However, to date, no comprehensive bibliometric analysis has systematically evaluated the relationship between GBM and the BBB over the past three decades. Objective: This study provides an overview of research progress on GBM and the BBB, with emphasis on structural and functional changes of the BBB. It also identifies current research hotspots, predicts emerging trends, and offers insights for future investigations. Method: Literature from the past 30 years was retrieved from the Web of Science Core Collection and PubMed. Bibliometric analysis was performed using the R programming language, and data visualization was conducted with VOSviewer, CiteSpace, and Tableau. Result: Since 2015, publication output and academic influence in this field have increased exponentially. The United States leads in both publication volume and citation count, and engages in extensive international collaborations. Conclusion: This study offers a comprehensive overview of GBM-BBB research trends over the past 30 years. It advances the understanding of their interplay and provides theoretical guidance for overcoming the BBB and improving GBM outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.