ArticleFrontiers in oncology2025
A case report on IDH-mutant astrocytoma, CNS WHO grade 4: multi-omic characterization of untreated clinical progression.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- From Data to Decision: Integrating Bioinformatics into Glioma Patient Stratification and Immunotherapy Selection.International journal of molecular sciences · 2026Review
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6 authors.
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Abstract
Background: The natural history of untreated IDH-mutant astrocytoma, CNS WHO grade 2, progressing to astrocytoma grade 4 remains poorly characterized. Methods: A 67-year-old woman with a histologically confirmed grade 2 astrocytoma developed a spatially adjacent grade 4 lesion after eight years without therapeutic intervention. Tumor tissue and peripheral blood were analyzed using integrated genomic, transcriptomic, and immune profiling. Results: The central region retained grade 2 histology, while the peripheral region exhibited grade 4 features. Both shared mutations in Conclusion: This case highlights the clonal progression of an IDH-mutant astrocytoma from grade 2 to grade 4, potentially driven by additional mutations and immune remodeling. These exploratory findings suggest candidate mechanisms of glioma evolution and may inform adoptive T-cell therapy approaches.
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