ReviewFrontiers in oncology2025
Immunotherapy in the perioperative management of esophageal squamous cell carcinoma: recent developments.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Response-adapted perioperative therapy for resectable esophageal cancer in the immunotherapy era: a narrative review.Journal of thoracic disease · 2026Review
- Development of Second Primary Malignancies in Long-term Survivors of Unresectable Esophageal Cancer.Cancer diagnosis & prognosisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Esophageal cancer ranks among the most prevalent malignancies of the gastrointestinal tract. Esophageal squamous cell carcinoma (ESCC), accounting for approximately 90% of all esophageal cancer (EC) cases, represents the dominant pathological subtype. For locally advanced ESCC at clinical stages II-IVA, surgery-based multidisciplinary treatment remains the primary management strategy. Despite concerted efforts, long-term outcomes for ESCC patients remain suboptimal. Recent years have witnessed significant advancements in immunotherapy, with PD-1/PD-L1 inhibitors demonstrating promising efficacy across various malignancies, particularly in ESCC. This review synthesizes the current landscape of perioperative immunotherapy for resectable ESCC, emphasizing the role of immune checkpoint inhibitors in the perioperative setting. Additionally, it highlights unresolved challenges in ongoing clinical research and provides insights into future directions for ESCC immunotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.