Evidence map›Paper›PMID 41079047›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Effect of walking with an active ankle exoskeleton on the biomechanical responses of the lumbar spine.

Jose E Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Sridevi Nagaraja, Meredith K Owen, Michael A Samaan, Brian Noehren, Jaques Reifman

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jose E RubioDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Defense Health Agency Research & Development, Medical Research and Development Command, Fort Detrick, MD, United States.
Junfei TongDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Defense Health Agency Research & Development, Medical Research and Development Command, Fort Detrick, MD, United States.
Aravind SundaramurthyDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Defense Health Agency Research & Development, Medical Research and Development Command, Fort Detrick, MD, United States.
Anup PantDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Defense Health Agency Research & Development, Medical Research and Development Command, Fort Detrick, MD, United States.
Sridevi NagarajaDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Defense Health Agency Research & Development, Medical Research and Development Command, Fort Detrick, MD, United States.
Meredith K OwenDepartment of Physical Therapy, University of Kentucky, Lexington, KY, United States.
Michael A SamaanDepartment of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, United States.
Brian NoehrenDepartment of Physical Therapy, University of Kentucky, Lexington, KY, United States.
Jaques ReifmanDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Defense Health Agency Research & Development, Medical Research and Development Command, Fort Detrick, MD, United States.

Funding

Environmental Health Perspectives, NIEHS27302C0031 · NIEHS · 2008 to 2008
$1.2M
Quantifying the Mechanism and Impact of Hip Extensor Muscle Dysfunction During Aerobic Exercise in Hip OsteoarthritisK01AG073698 · NIA · UNIVERSITY OF KENTUCKY · PI Michael A Samaan · 2022 to 2026
$612k
NIA NIH HHS K01 AG073698NIEHS NIH HHS 27302C0031
6 · The paper itself

Abstract

Objective: Musculoskeletal injuries pose a health threat to U.S. Service members. In particular, the physical demands of walking and running with load carriage contribute to a high incidence of musculoskeletal injuries of the lower back. Active ankle exoskeleton devices are promising technologies that may help mitigate the impact of load carriage on the incidence of these injuries. However, the safe extended use of these devices requires an understanding of their beneficial or detrimental effects on the lumbar spine. In this pilot study, we investigated the impact of walking with an ankle exoskeleton device on lumbar biomechanical responses. Methods: We collected motion-capture data and computed tomography images for five young, healthy men walking with a 22.7 kg (50-lb) load for 5 km at a speed of 1.3 m/s, with and without an active ankle exoskeleton (ExoBoot EB60). We developed individualized musculoskeletal and finite-element models to characterize the effects of walking distance and ExoBoot use on the trunk flexion angle, joint reaction force at the L4-L5 joint, and stress on the L4-L5 intervertebral disc annulus. Results: While not statistically significant, we found that the peak trunk flexion angle and the peak annulus stress increased by 16% and 12%, respectively, after walking 5 km with the ExoBoot, and by 34% and 25%, respectively, without it. Similarly, the peak L4-L5 joint reaction force minimally increased by 4% with the ExoBoot, while it increased by 22% without the device. Conclusion: ExoBoot use likely attenuates the effect of fatigue on the lumbar spine induced by walking with load carriage.

Indexed as

exoskeletonload carriagelow-back injurylumbar biomechanicsmusculoskeletal model

Identifiers

PMID41079047
PMCPMC12507844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.