Differential effects of flunixin meglumine and meloxicam on TNF- α production in LPS-stimulated equine neutrophils in vitro.

Shuntaro Urayama, Ryo Muko, Masanori Muranaka, Hiroshi Mita, Minoru Ohta, Hiroshi Matsuda, Akane Tanaka

Abstract read

In one paragraph

Article in Veterinary and animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuntaro UrayamaAnti-doping Section, Equine Department, Japan Racing Association (JRA), 1-1-1 Nishishimbashi, Minato-ku, Tokyo 105-0003, Japan.

Ryo MukoLaboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo 183-8509, Japan.

Masanori MuranakaRacehorse Hospital, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-Shi, Shiga 520-3085, Japan.

Hiroshi MitaClinical Veterinary Medicine Division, Equine Research Institute, JRA, 1400-4 Shiba, Simotsuke-Shi, Tochigi 329-0412, Japan.

Minoru OhtaClinical Veterinary Medicine Division, Equine Research Institute, JRA, 1400-4 Shiba, Simotsuke-Shi, Tochigi 329-0412, Japan.

Hiroshi MatsudaLaboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo 183-8509, Japan.

Akane TanakaLaboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo 183-8509, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic inflammatory response syndrome (SIRS) induced by endotoxemia is usually secondary to colitis and is a major cause of high morbidity and mortality in horses. Non-steroidal anti-inflammatory drugs (NSAIDs), such as flunixin meglumine (FM) and meloxicam (MX), are used to improve clinical outcomes in SIRS/endotoxemia. These NSAIDs suppress tumor necrosis factor-alpha (TNF-α) levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the inhibitory effects of FM and MX on TNF-α in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs) and neutrophils

Indexed as

EndotoxemiaEquineFlunixin meglumineMeloxicamNeutrophilsNSAIDsTNF-α

Identifiers

PMID41078983

DOI10.1016/j.vas.2025.100513

PMCPMC12510212

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.