Evidence map›Paper›PMID 41078974›Full record

ArticlemicroPublication biology2025

Characterization and Radiation Response of Cancer-Associated Fibroblasts isolated from Glioblastoma.

Caroline Delmas, Elisabeth Cohen-Jonathan-Moyal, Catherine Seva

Abstract read
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Caroline DelmasOncopole Claudius Regaud, IUCT-Oncopole, Toulouse, France.
Elisabeth Cohen-Jonathan-MoyalOncopole Claudius Regaud, IUCT-Oncopole, Toulouse, France.
Catherine SevaCentre de Recherches en Cancérologie de Toulouse, CRCT, Université de Toulouse, INSERM, CNRS, Toulouse, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis and strong resistance to radiotherapy. While cancer-associated fibroblasts (CAFs) are known in epithelial cancers, their presence in GBM has only recently been identified. In this study we isolated GBM-derived CAFs and confirmed their identity with specific markers. After irradiation (4-6 Gy), these CAFs showed no morphological or phenotypic changes and maintained viability, demonstrating radioresistance. The results indicate that CAFs may play a key role in GBM's resistance to treatment, underlining the need for further research on their role in radiotherapy failure.

Identifiers

PMID41078974
PMCPMC12514554

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.