ArticleArchives of medical science : AMS2025
Evaluation for CpG island methylation of FASN and SREBP promoter in Mongolian gerbil NAFLD model.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Evaluation methods of hepatic steatosis: From conventional techniques to emerging biomarkers.World journal of hepatology · 2026Review
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2 authors.
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Abstract
Introduction: Methylation of the CpG island in the promoter and its nearby area is one of the most important ways to inhibit gene expression. The aim of this study was to examine the potential relationship between CpG island methylation for fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP-1). Material and methods: Ten newborn gerbil pups formed the NB group, 10 adult gerbils with a normal diet formed the control group, 10 adult gerbils with a high-fat diet formed the nonalcoholic fatty liver disease (NAFLD) group, and 10 8-month-old gerbils formed the aged group. Blood and liver samples were collected for serum lipid detection and histopathology. A pyrosequencing technique was employed to determine the methylation rate. Then, the transcription and expression levels for FASN and SREBP-1 were verified. Results: Serum cholesterol and triglyceride were significantly increased in NAFLD and aged groups (vs. control, Conclusions: Expression of the SREBP gene tended to decrease, while expression of the FASN gene tended to increase with age and disease development. FASN and SREBP-1 methylation might be a new method to evaluate an NAFLD animal model and an available target for genetic marker screening.
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