ArticleArchives of medical science : AMS2025
Sleep disturbances and heart failure: observational study and Mendelian randomization study.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Unraveling the impact of neonatal jaundice on allergic diseases: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Age-Dependent Association Between Insomnia and Body Mass Index Among Young Women: Evidence from a Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Illuminating the sleep-heart failure connection - time to be woken up by the evidence.Archives of medical science : AMS · 2025Article
- Causal association between sleep traits and diabetic nephropathy.Archives of medical science : AMS · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Sleep disturbances are prevalent among patients with heart failure (HF) and may trigger acute exacerbations of the condition. However, the causal relationship between sleep disturbances and HF remains uncertain. This study aimed to explore the association and potential causal relationship between sleep disturbances and HF. Material and methods: Observational study: NHANES data (2005-2008) involving 10,432 participants. Sleep disturbances defined as insomnia, sleep disorders, difficulty falling asleep, trouble sleeping, and nocturnal awakening. Mendelian randomization (MR) study: Genetic variants linked to sleeplessness were obtained from GWAS datasets. MR two-sample analysis was conducted using summary statistics from sleeplessness and HF GWASs. Results: After full adjustment, the association between insomnia and HF remained significant, with an OR of 5.10 (1.81-14.33, Conclusions: Our study identified a correlation between sleep disturbances and HF, potentially suggesting a causal relationship. Addressing sleep disturbances may be a key strategy in reducing the risk of HF.
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