Evidence map›Paper›PMID 41078771›Full record

ArticleACS omega2025

Base-Mediated Tandem Michael Addition and SuFEx Cyclization for the Synthesis of Sultone-Containing Spirooxindoles.

Kimberleigh B Govender, Sandile B Simelane, Lloyd C Chetty, Hendrik G Kruger, Thavendran Govender, Per I Arvidsson, Tricia Naicker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kimberleigh B GovenderCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban 4001, South Africa.
Sandile B SimelaneCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban 4001, South Africa.
Lloyd C ChettyCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban 4001, South Africa.
Hendrik G KrugerCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID https://orcid.org/0000-0003-0606-2053
Thavendran GovenderDepartment of Chemistry, University of Zululand, Private Bag X1001, KwaDlangezwa 4001, South Africa.ORCID https://orcid.org/0000-0003-2511-2503
Per I ArvidssonCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban 4001, South Africa.
Tricia NaickerCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID https://orcid.org/0000-0002-7134-6258

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulfur-containing spirooxindoles are recognized for their significant biological activity, yet accessing these compounds with diverse heteroatoms in the spirocyclic core has remained challenging. This study introduces a simple and efficient base-mediated tandem Michael addition reaction and SuFEx cyclization to synthesize novel sultone-containing spirooxindoles. The transformation occurred in a green solvent, which proved essential in suppressing side reactions, leading to the successful synthesis of 20 novel sultone-spirooxindoles and two sulfonates that are resistant to cyclization. Additionally, a chiral variant of the reaction was explored, laying the groundwork for the future development of enantioselective methods.

Identifiers

PMID41078771
PMCPMC12508956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.