ArticleACS omega2025
General Approach for the Synthesis of Triazinyl Phosphoramidate Oligonucleotides via the Staudinger Reaction with the Use of 2‑Azido-4,6-dichloro-1,3,5-triazine.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- The Staudinger reaction: a versatile synthetic tool for the construction of β-lactams, heterocycles, and functional organic molecules.RSC advances · 2026Review
- Amidation of Phosphonoacetate-Modified Oligonucleotides and Evaluation of the Properties of the Synthesized Oligonucleotides.Organic letters · 2026Article
- Expanding the Range of Methods for Obtaining Diverse Representatives of Sulfonyl Phosphoramidate Oligonucleotides.ACS omega · 2026Article
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2 authors.
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Abstract
Developing the new types of phosphate-modified oligonucleotides and methods for their synthesis is of great interest in nucleic acid chemistry, since such derivatives could be applied as diagnostic and therapeutic tools. In the present study, our previously reported synthesis of oligonucleotide bearing two dodecyl residues on the triazine core was expanded to a general approach of synthesis of a novel class of phosphate-modified nucleic acids, triazinyl phosphoramidate oligonucleotides (TPO). The proposed approach for obtaining TPO is based on the Staudinger reaction between highly reactive 2-azido-4,6-dichloro-1,3,5-triazine and the phosphite triester intermediate of oligonucleotide solid-phase synthesis, with the following β-elimination of 2-cyanoethyl protective group and substitution of chlorine atoms with various amine residues. The formation of the triazinyl phosphoramidate bond was confirmed by carrying out
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