ArticleMediators of inflammation2025
Identification and Validation of Pyroptosis-Associated Gene Signature in Primary Sjögren's Syndrome.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Molecular Insights into Oral Manifestations in Sjögren's Disease.International journal of molecular sciences · 2026Review
- ZBP1 and IFI16: novel innate sensors and inflammation regulation under infection stress.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pyroptosis, a form of programmed cell death, has been implicated in autoimmune diseases (ADs) pathogenesis. However, its role in primary Sjögren's syndrome (pSS) remains unclear. This study aims to identify pyroptosis-related gene (PRG) signatures in pSS. Methods: Three datasets were obtained from the Gene Expression Omnibus (GEO) database to analyze the gene expression profiles in pSS. Differentially expressed genes (DEGs) were intersected with PRGs to identify pyroptosis-related DEGs (PRDEGs). Functional enrichment was assessed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Key genes were identified using the least absolute shrinkage and selection operator (LASSO) and support vector machine (SVM) analyses. A diagnostic model was constructed using logistic regression. mRNA-microRNA (miRNA) and mRNA-transcription factor (TF) interaction networks were constructed. Immune cell infiltration (ICI) was analyzed using cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORTs) and single-sample gene set enrichment analysis (ssGSEA). Experimental validation was performed in nonobese diabetic (NOD)/ShiLtj mice using reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blotting, and immunofluorescence and was further validated using immunofluorescence in pSS patient samples. Results: A total of 489 DEGs were identified, of which 22 were pyroptosis-related. GO/KEGG analysis revealed enrichment in immune response regulation, pyroptosis, and the positive regulation of receptor signaling pathways. LASSO and SVM analyses identified eight key genes ( Conclusions: PECAM1, IFI16, AIM2, and MPEG1 were identified as PRG signatures and potential biomarkers in pSS, providing novel insights into pSS pathogenesis.
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