ArticleJournal of orthopaedic case reports2025
Correlation between Vitamin D Levels and Healing Time in Lower Limb Fractures.
Article in Journal of orthopaedic case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Predictors of Delayed Union Following Locking Compression Plate Fixation of Tibial Shaft Fractures: A Prospective Observational Study.Journal of orthopaedic case reports · 2026Article
- Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.Journal of orthopaedic case reports · 2026Article
- Correlation of serum vitamin D, calcium-phosphorus metabolism and functional outcome in osteoporotic fractures.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim and Background: Vitamin D plays a central role in calcium-phosphate metabolism and bone healing. Deficiency is common among fracture patients and may contribute to delayed union, particularly in weight-bearing lower-limb fractures. The purpose of this study was to assess the relationship between lower limb fracture healing time and baseline serum Vitamin D levels. Materials and Methods: A prospective, observational, multi-center study was conducted from January 2022 to December 2024. Adult patients with acute lower-limb fractures were enrolled. Within a week following the injury, baseline serum 25-hydroxyvitamin D levels were assessed. The levels of Vitamin D were categorized as adequate (>30 ng/mL), inadequate (20-30 ng/mL), or deficient (<20 ng/mL). Healing time was recorded clinically (pain-free weight bearing) and radiologically (radiographic union scale for tibial fractures score ≥12). Statistical analysis included correlation and regression models. Results: A total of 120 patients (mean age 44.8 ± 13.2 years, M:F = 1.6:1) were included. The mean Vitamin D level was 21.6 ± 8.4 ng/mL; deficiency was present in 45.0%, insufficiency in 31.7%, and sufficiency in 23.3%. The mean healing time was 16.4 ± 3.8 weeks, with faster healing in sufficient patients (14.8 ± 2.9 weeks) compared to insufficient (16.7 ± 3.2 weeks) and deficient (17.9 ± 3.9 weeks) groups (P < 0.001). Vitamin D levels continued to be an independent predictor on regression analysis (β = -0.41, P < 0.001) and had a negative correlation with healing time (r = -0.62, P < 0.001). Conclusion: Higher incidences of delayed union and longer healing durations were linked to lower baseline Vitamin D levels. Patients with lower limb fractures may have better results with routine screening and deficit repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.