ArticleFrontiers in global women's health2025
Risk factors for maternal pyrexia, infection and sepsis in four hospitals providing maternity care in New South Wales, Australia: a cohort study.
Article in Frontiers in global women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Maternal sepsis is a leading cause of maternal mortality. In Australia, it is the third most common cause of maternal death despite a low overall maternal death rate (5.8 per 100,000 births). The objective of this study was to examine risk factors for maternal pyrexia, infection and sepsis, adherence to WHO maternal antibiotic prophylaxis guidelines and resistance patterns in women with Group B Streptococcus (GBS). Methods: We conducted a retrospective observational cohort study using routinely collected data from four hospitals providing maternity care in New South Wales, Australia, including pathology data from one hospital. Women who gave birth between January 1, 2018, and December 31, 2020, were included. Definitions for pyrexia, infection, and sepsis were based on medical notes and the obstetrically modified Sequential Organ Failure Assessment criteria. We used multivariable logistic regression to identify risk factors and descriptive statistics to evaluate antibiotic prophylaxis adherence and resistance. Results: Out of 23,016 women, 2,650 (11.5%) experienced pyrexia, infection, or sepsis. Women with pyrexia, infection, or sepsis were more likely to report a history of substance use and less likely to receive influenza vaccination. Hospital-based (non-continuity) midwifery care, nulliparity, and emergency Caesarean section and instrumental vaginal birth were associated with increased risk of pyrexia, infection, or sepsis. Documented adherence to antibiotic prophylaxis guidelines was suboptimal, with 35% of Caesarean sections and 29% of severe perineal tear cases documented as receiving antibiotics. In the subset of women with available pathology data, GBS screening was performed in 72.6% of cases, with 19.4% testing positive. Resistance to erythromycin (33.4%) and clindamycin (30.9%) was high, though no resistance to penicillin or ampicillin was observed. Conclusion: Demographic and labour/birth factors conveying an increased risk of pyrexia, infection or sepsis were broadly in line with previous studies. Adherence to WHO prophylaxis guidelines was poorly documented and increased rates of antibiotic resistance to erythromycin and clindamycin were observed. Ongoing monitoring of resistance patterns and improving guideline adherence is important to optimise care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.