ArticleFrontiers in microbiology2025
Temporal dynamics and forecasting of respiratory viral infections during and after the SARS-CoV-2 pandemic (2020-2027): a multiplex PCR and ARIMA-based study.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Post‑pandemic shifts in the age distribution of RSV, influenza A, and rhinovirus infections: A four‑year pediatric surveillance study.BMC public health · 2026Article
- Pairwise Respiratory Viral Co-Detection Patterns Before, During, and After the COVID-19 Pandemic: An 18-Year Multiplex PCR Surveillance Study.Microorganisms · 2026Article
- From Triplex to Quadruplex: Enhancing CDC's Respiratory qPCR Assay with RSV Detection on Panther FusionMicroorganisms · 2026Article
- Age-stratified respiratory viral detection patterns and exploratory environmental associations in a tertiary-care hospital testing cohort in Istanbul, Türkiye.Frontiers in microbiology · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
Introduction: Respiratory viruses are the leading cause of acute respiratory tract infections in both children and adults, with significant morbidity and healthcare burden. Before the COVID-19 pandemic, these pathogens typically exhibited predictable seasonal circulation patterns. However, the pandemic markedly disrupted this seasonality, leading to reduced viral detection during lockdowns and unusual peaks in subsequent periods. Objective: This study aimed to identify respiratory pathogens in LRTI patients using multiplex PCR and to assess changes in virus distribution during and after the COVID-19 pandemic across age groups. Methods: A total of 748 nasopharyngeal swab samples (one per patient) collected between March 2020 and November 2024 were retrospectively analyzed using the QIAstat-Dx Respiratory Panel, a multiplex PCR assay de tecting 19 respiratory viruses including SARS-CoV-2, influenza viruses, respiratory syncytial virus (RSV), and Rhinovirus/Enterovirus. Statistical analyses, including multivariate logistic regression, assessed viral positivity predictors. Additionally, the Autoregressive Integrated Moving Average (ARIMA) time-series model was used to evaluate trends and predict respiratory virus activity through 2027. Results: The cohort comprised 60.4% males and 39.6% females, with 14.4% pediatric (0-18 years) and 85.6% adult patients. Respiratory viruses were detected in 43.6% of samples, with significantly higher positivity in children (71.5%) compared to adults (40%) ( Discussion: Following the relaxation of public health measures, there was a marked resurgence of non- SARS-CoV-2 respiratory viruses, particularly in children, indicating a possible shift in viral epidemiology. These findings emphasize the critical need for ongoing surveillance and targeted interventions, especially in pediatric populations, to mitigate future respiratory viral disease burdens.
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