Evidence map›Paper›PMID 41078487›Full record

ArticleVirus evolution2025

Decoding VZV's evolutionary arsenal: how Beijing strains use recombination and adaptive mutations to thrive.

Xiaotian Han, Changcheng Wu, Yao Deng, Lingfang Zhang, Lantao Wang, Zhongxian Zhang, Xuejie Zhang, Chen Mai, Wenjie Tan, Yang Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. An explainable machine learning model predicts pediatric varicella encephalitis.Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaotian HanDepartment of Pathogenic Biology, Hebei Medical University, Shijiazhuang 050017, China.ORCID https://orcid.org/0009-0006-0349-7544
Changcheng WuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.ORCID https://orcid.org/0000-0002-2428-8630
Yao DengNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Lingfang ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Lantao WangThe Fourth Hospital of Hebei Medical University, Shijiazhuang 050010, China.
Zhongxian ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Xuejie ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Chen MaiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Wenjie TanDepartment of Pathogenic Biology, Hebei Medical University, Shijiazhuang 050017, China.
Yang ZhaoBeijing You'an Hospital, Capital Medical University, Beijing 100069, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella-zoster virus (VZV), a highly contagious α-herpesvirus, causes chickenpox and shingles. Although vaccines have been widely deployed, breakthrough infections still occur occasionally. Therefore, genomic surveillance of VZV remains essential. This study collected samples from 28 VZV-infected patients in Beijing, generating 25 complete viral genome sequences. These strains exhibited high genomic similarity and all belonged to Clade 2, which we further subdivided into five subclades with distinct characteristic variants. Most newly sequenced strains carried the A20795T (gC: Ser107Thr) mutation and were classified as Clade 2b.4. Recombination analysis identified 32 putative recombination events, including both inter- and intra-clade types. Genes with diverse functions are under differential selective pressures, with 3-20 positively selected sites detected in

Indexed as

adaptive mutationsclade 2b.4recombinationvaricella-zoster viruswhole-genome sequencing

Identifiers

PMID41078487
PMCPMC12513170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.