ArticleFood science & nutrition2025
Comparison of Antioxidant and Anti-Melanogenic Activity of γ-Oryzanol and Gallic Acid by Inhibiting Tyrosinase Activity in B16F10 Mouse Melanoma Cells.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Comparison of Antioxidant and Anti-Melanogenic Activity of γ-Oryzanol and Gallic Acid by Inhibiting Tyrosinase Activity in B16F10 Mouse Melanoma Cells.Food science & nutrition · 2025Article
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6 authors.
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Abstract
Rice bran is abundant in gallic acid, and γ-oryzanol comprises a mixture of ferulic acid esters and phytosterols. We compared the antioxidant and anti-melanogenic activities of gallic acid and γ-oryzanol to treat disorders caused by hyperpigmentation. The antioxidant activity was measured by 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH) and ferric-reducing antioxidant power (FRAP) methods. Then, its effects on viability, reactive oxygen species (ROS) production, mushroom tyrosinase, and melanin content were investigated on B16F10 murine melanoma cell line. The antioxidant effects of γ-oryzanol were higher than those of gallic acid in DPPH and FRAP tests. γ-oryzanol and gallic acid did not show a significant cytotoxic effect and also reduced the amount of ROS. In addition, the reduction of mushroom tyrosinase activity in γ-oryzanol was more than that in gallic acid. A decrease in melanin content was observed in γ-oryzanol and gallic acid. So, it can be concluded that γ-oryzanol has more antioxidant and higher inhibitory effects in the expression pathway of proteins involved in melanin synthesis in B16F10 cells than gallic acid.
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