ArticleJournal of experimental orthopaedics2025
The promising potential of intra-articular losartan combined with scaffold implantation for osteochondral repair: a comparative study in a rabbit model against osteochondral autograft transplantation.
Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The promising potential of intra-articular losartan combined with scaffold implantation for osteochondral repair: a comparative study in a rabbit model against osteochondral autograft transplantation.Journal of experimental orthopaedics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to compare the radiological, macroscopic, biomechanical and histological outcomes of osteochondral autograft transplantation (OAT) and a combination of intralesional scaffold with intra-articular losartan injection in a rabbit model of osteochondral injury. Methods: Twelve rabbits received bilateral osteochondral defects (4 × 4 mm) in the trochlear region of both knees and were divided into two groups. Group A received scaffold implantation with intra-articular losartan (1 mg per knee, injected in 0.1 mL of solution), while Group B underwent OAT with re-implantation of the original plug. After 6 months, bilateral knee magnetic resonance imaging (MRI), macroscopic, histological and biomechanical assessments were performed. Results: Macroscopic examination demonstrated that the defect areas were filled and integrated with the surrounding cartilage. MRI evaluations revealed complete closure of the osteochondral defects. Histological evaluation using Wakitani scores showed no statistically significant difference between the groups (Group A: 3.63 ± 2.13, Group B: 2.63 ± 2.01, Conclusions: The scaffold-losartan combination may offer a promising, less invasive alternative to traditional OAT for osteochondral defect repair. Level of Evidence: N/A.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.