ArticleFrontiers in physiology2025
Identification and functional analysis of circular RNAs in intervertebral disc lesion tissues from spinal tuberculosis patients.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Spinal tuberculosis (STB) is characterized by an insidious onset, nonspecific clinical manifestations, and diagnostic challenges in early stages. Circular RNAs (circRNAs), a class of stable single-stranded endogenous RNAs with covalently closed-loop structures, play crucial regulatory roles in various biological processes. However, their involvement in STB pathogenesis remains largely unexplored. Methods: We collected intervertebral disc tissue specimens and peripheral blood samples from STB patients. CircRNAs sequencing was performed on three representative lesion tissues, followed by comprehensive screening and validation in both tissue and blood samples to elucidate the functional mechanisms of circRNAs in STB. Results: Chip sequencing indicated that a total of 1,396 circRNAs were differentially expressed (fold change >2, Conclusion: The differentially expressed circRNAs identified in intervertebral disc lesions of STB patients demonstrate significant involvement in disease pathogenesis, positioning them as promising candidates for both diagnostic and therapeutic targeting. Specifically, hsa_circ_0001021, hsa_circ_0043898, and hsa_circ_0093669 exhibit robust potential as peripheral blood-based diagnostic biomarkers for STB. When combined with conventional inflammatory markers ESR and CRP, these circRNAs significantly enhance diagnostic accuracy. Furthermore, longitudinal monitoring revealed their unique value in postoperative therapeutic evaluation, with expression levels showing strong correlation with treatment response.
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