ArticlePlant biotechnology journal2026
A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris.
Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Effects of Solid-State Fermentation byFoods (Basel, Switzerland) · 2026Article
- Article
- Scoparone-Induced Phase Separation of ZDHHC12 Drives Ferroptosis via ATG12 S-palmitoylation and Ferritinophagy in Liver Fibrosis.Research (Washington, D.C.) · 2026Article
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Authors and funding
16 authors.
Funding
Abstract
Artemisia capillaris, a traditional Chinese medicinal plant, has displayed favourable effects in the treatment of jaundice, inflammation of the liver and cholecystitis for thousands of years. However, the biosynthesis of scoparone, the major active component in A. capillaris, remains unclear. Here, a full-length transcriptomic and integrated metabolomic dataset of A. capillaris was generated for the first time. A nearly complete map of the biosynthesis pathway of scoparone was subsequently proposed. Notably, a novel O-methyltransferase, AcOMT1, which catalyses the methylation of scopoletin and isoscopoletin as the final step in the biosynthesis of scoparone, was annotated and characterised using a weighted gene correlation network, phylogenetic analysis, subcellular localisation analysis and enzyme assays. Molecular docking and dynamics simulations demonstrated that AcOMT1 has a stronger and more stable affinity for scopoletin than for isoscopoletin, explaining its greater efficiency and preference for the methylation of scopoletin. Ultimately, by coexpressing AcOMT1, along with the crucial genes responsible for scopoletin biosynthesis in Nicotiana benthamiana, we developed a system for scoparone biosynthesis, yielding 3.03 μg.g
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