Trial reportJournal of cosmetic dermatology2025
Adipose Tissue-Derived Stem Cells Enhance Dermogenesis of Post-Acne Depressed Spots.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06135519 (Dermogenesis With Mesenchymal Stem Cells), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dermogenesis With Mesenchymal Stem Cells: A Fabulous Remedy For Post Acne Depressed Spots
Who cites it
1 citing paper in PubMed.
- Adipose Tissue-Derived Stem Cells Enhance Dermogenesis of Post-Acne Depressed Spots.Journal of cosmetic dermatology · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-acne depressed spots appear due to localized fat atrophy and disruption of the dermis. Surgical excision of acne spots is challenging; thus, novel management is required.
aimsThe aim of this study is to compare the long-term effects of conventional and ex vivo expanded ASCs enriched fat for the treatment of post-acne spots. PATIENTS/
methodsAfter informed consent, 40 patients having post-acne spots on the face were recruited and, after explaining, placed in two groups depending upon their choice. In lipofilling-only group (LF), adipose tissue was harvested, prepared, and injected intradermally and subdermally in the depressed spots. In ASC-enriched lipofilling group (ASC-LF), fat waɓg' enriched with cultured ASCs before injection. Improvement of the contour was noted clinically after 1 year. Differences in dermal thickness were confirmed histologically on punch biopsies. Evaluation of pictures was done by two consultant plastic surgeons blinded to the technique. Similarly, the satisfaction of patients was also noted.
resultsMean age of patients was 26.32 (±3.34) and 72% of patients were females. Cheeks only were involved in 57% of cases while cheeks associated with involvement of lateral forehead in 29% of cases, nose in 11% of cases, and chin in 3% of cases. In ASC-LF group, improvement in dermal thickness (1.2 ± 0.6 mm) was higher compared to LF group (0.5 ± 0.3 mm). The mean scores of patients and physician satisfaction were higher in ASC-LF group.
conclusionThis novel strategy significantly improved the acne-related contours by increasing dermal thickness.
trial registrationwww. CLINICALTRIALS: gov: NCT06135519.
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