ArticleVeterinary surgery : VS2025
Black thyroid in a dog on long-term doxycycline therapy.
Article in Veterinary surgery : VS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Black thyroid in a dog on long-term doxycycline therapy.Veterinary surgery : VS · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo increase awareness of black thyroid in dogs and to prevent unnecessary total thyroidectomy. A benign condition called "black thyroid" has been documented in greater than 250 people on chronic minocycline therapy, and rarely in animals. To our knowledge this is the first report of black thyroid in an animal secondary to doxycycline therapy. STUDY
designCase report. ANIMAL: One 10 year-old female spayed Collie-cross dog.
methodsA dog on long-term doxycycline underwent a right parotid sialoadenectomy and left thyroidectomy to remove associated tumors. Black pigmentation of both thyroid lobes was observed intraoperatively. The left thyroid gland and associated nodule were excised, leaving the right lobe intact.
resultsHistopathology of the left thyroid nodule and right parotid salivary gland were consistent with thyroid follicular-compact cell carcinoma with metastasis. Finely granular brown pigment was present multifocally within the cytoplasm of many of the thyroid follicular cells and extracellularly within the colloid as irregular gray to brown glassy aggregates. The pigment was negative for iron and calcium and had minimal to no immunoreactivity for melanin.
conclusionThese findings aligned with those reported for the condition black thyroid in humans. At this time, there is no evidence that performing a thyroidectomy is necessary or appropriate for black thyroid. Veterinary surgeons should be aware that dogs on long-term doxycycline therapy may have this discoloration, so unnecessary total thyroidectomy can be prevented in affected animals.
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