Evidence map›Paper›PMID 41078149›Full record

ArticleMagnetic resonance in medicine2026

A Nonlinear Single Channel Gradient Insert for Prostate Diffusion Imaging.

Nahla M H Elsaid, Horace Z Zhang, Ates Fettahoglu, Chenhao Sun, Andrea De Simone, Terence Nixon, Andrew Dewdney, Dana C Peters, Jeffrey Weinreb, Todd Constable and 1 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nahla M H ElsaidRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-8832-3087
Horace Z ZhangRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0009-0001-1416-2380
Ates FettahogluRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Chenhao SunRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Andrea De SimoneRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Terence NixonRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Andrew DewdneySiemens Healthineers AG, Erlangen, Germany.
Dana C PetersRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-7556-4642
Jeffrey WeinrebRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Todd ConstableRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Gigi GalianaRadiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

Inside-Out Nonlinear Gradients to Improve Diffusion MRIR01CA264851 · NCI · YALE UNIVERSITY · PI GALIANA, GIGI · 2021 to 2025
$1.9M
NCI NIH HHS R01 CA264851NIH HHS R01CA264851
6 · The paper itself

Abstract

purposeThis paper reports on the technical performance of a nonlinear "inside-out" gradient and its feasibility and safety for diffusion encoding in humans. The tested hardware is a solenoidal coil with a 10 cm diameter, positioned at the isocenter of the magnet bore, designed to generate strong gradients within the surrounding volume.

methodsVarious methods were used to characterize the spatial, temporal, mechanical, and acoustic properties of the gradient coil. ADC mapping studies show the feasibility of diffusion-weighted imaging and ADC mapping in phantoms and humans.

resultsThe hardware was found to generate high gradient strengths (> 200 mT/m) for expected prostate regions whilst heating, noise, and eddy currents remained within acceptable limits for human scanning. Despite its unconventional geometry and compact form factor, standard calibration methods were effective, enabling accurate ADC mapping in both phantoms and human subjects. No peripheral nerve stimulation (PNS) was reported, even at maximum slew rates and gradient amplitudes.

conclusionInside-out nonlinear gradients can be calibrated with conventional techniques, and the hardware can provide a more convenient approach to strong diffusion weighting of targeted organs.

Indexed as

Diffusion Magnetic Resonance ImagingProstateEquipment DesignHumansMalePhantoms, ImagingReproducibility of Resultsdiffusion magnetic resonance imagingmagnetic resonance imagingnonlinear gradient coilprostate ADC mapping

Identifiers

PMID41078149
PMCPMC13006828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.