ArticleMolecular pharmaceutics2025
Arabinogalactan-Functionalized Gold Nanoparticles Demonstrated Remarkable Anticancer Therapeutic Effect against Hepatocellular Carcinoma.
Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The treatment and prognosis of cancer remain highly challenging due to its complex and multifaceted nature. In the paradigm of nanomedicine, nanotechnology has gained huge attention in cancer therapeutics. The unique physicochemical properties offered by gold nanoparticles (AuNPs) in targeted drug delivery and anticancer therapy favor their implications in cancer therapeutics. However, surface modification, particularly with polysaccharides, can further optimize the function of gold nanoparticles. Among others, the advantages offered by arabinogalactan (AG) make it a suitable candidate for coating gold nanoparticles. The present study reported the anticancer therapeutic potential of AG-AuNPs against liver cancer. The synthesized AG-AuNPs were characterized for UV-visible spectrum, hydrodynamic size, zeta potential, core size, bonding and functional groups, crystalline nature, and elemental composition. The compound was then evaluated for its stability in biological fluids followed by
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