Evidence map›Paper›PMID 41078090›Full record

ArticleJournal of cellular and molecular medicine2025

Reduced Growth and Inflammation in Lrp5

Aureli Luquero, Noelia Pimentel, Gemma Vilahur, Lina Badimon, Maria Borrell-Pages

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Reduced Growth and Inflammation in Lrp5Journal of cellular and molecular medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aureli LuqueroMolecular Pathology and Therapeutic of Ischemic and Atherothrombotic Diseases, Sant Pau Research Institute (IR-Sant Pau), Barcelona, Spain.
Noelia PimentelMolecular Pathology and Therapeutic of Ischemic and Atherothrombotic Diseases, Sant Pau Research Institute (IR-Sant Pau), Barcelona, Spain.
Gemma VilahurMolecular Pathology and Therapeutic of Ischemic and Atherothrombotic Diseases, Sant Pau Research Institute (IR-Sant Pau), Barcelona, Spain.
Lina BadimonMolecular Pathology and Therapeutic of Ischemic and Atherothrombotic Diseases, Sant Pau Research Institute (IR-Sant Pau), Barcelona, Spain.
Maria Borrell-PagesMolecular Pathology and Therapeutic of Ischemic and Atherothrombotic Diseases, Sant Pau Research Institute (IR-Sant Pau), Barcelona, Spain.ORCID 0000-0002-1759-9756

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca INVESTIGO-ProgramAgencia Estatal de Investigación PID2019-107160RB-I00Agencia Estatal de Investigación PID2021-128891OB-I00Agencia Estatal de Investigación PLEC2021-007664- NextGenerationEUAgencia Estatal de Investigación PRE2020-096422Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya 2021SGR01006Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya CERCA programFundació la Marató de TV3 202304-10Instituto de Salud Carlos III CIBERCV CB16/11/00411Instituto de Salud Carlos III ERA-CVD JTC 202-023/AC 209-00054Instituto de Salud Carlos III PI23/00589Sociedad Española de Cardiología FEC 2022
6 · The paper itself

Abstract

Obesity is a major cause of chronic disease morbidity-mortality. Understanding the mechanisms triggering its promotion will allow the development of effective treatments. Cardiovascular diseases are associated with high-fat diet ingestion; however, how adiposity is distributed in relation to fat intake is not known. The lipoprotein receptor LRP5 participates in lipid handling in several cells. Whether LRP5 and its effector canonical WNT signalling pathway are involved in high-fat diet-induced adipose tissue distribution remains unknown. We fed Wt and Lrp5

Indexed as

Adipose TissueInflammationLow Density Lipoprotein Receptor-Related Protein-5AdipocytesAnimalsCell ProliferationDiet, High-FatHumansMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutObesityWnt Signaling PathwayLow Density Lipoprotein Receptor-Related Protein-5Lrp5 protein, mouseadipose tissuecanonical WNT signallingimmune infiltrationinflammationlipoprotein receptor

Identifiers

PMID41078090
PMCPMC12516158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.